波士顿RNA公司招聘免疫学和制剂人才

公司背景：

一家mRNA 生物制药公司,成立于 2021 年,在波士顿和上海设有研发中心。利用其 mRNA 技术平台和战略合作伙伴关系,公司正在建立创新 mRNA 疫苗和治疗候选药物的管道,以治疗新兴市场和全球医疗需求未得到满足的各种疾病。公司由全球知名VC孵化，经验丰富的管理团队领导,并得到世界知名的科学顾问委员会的支持。 

1）Senior/Principal Scientist of Immunology 

Responsibilities:

• Search and read relevant literature to generate target hypothesis and make proposals.

• Design, construct, and test expression and activity of vaccines in a variety of assays.

• Build and conduct in vitro experiments to investigate target mechanisms of action

•Work as part of a multi-disciplinary scientific team to implement experimental plans and achieve project goals.

• Supervise and communicate results of experiments with CROs  for  Animal study.

Required Qualifications:

• Ph.D. in Immunology or a related field with 3 years industry experience.

• Proficiency in Immunology skills, such as invitro and invivo validation, including

Pseudovirus-based neutralization, T cell assay and ELISpot.

Preferred Qualifications:

• Experience with vaccine study design.

• Experience with Immunology.

• Experience with assay development or binding assay.

• Experience with experiment design and data analysis. 

2）Senior/principal Scientist of Nucleic Acid Delivery

Job Duties:

1. Act as a subject-matter expert for nucleic acid delivery technologies and provide key input on discovery and early development programs

2. Apply knowledge of nucleic acid delivery to prepare and characterize RNA and delivery vehicle including lipid nanoparticles.

3. Characterization and analysis of biophysical nanoparticle attributes

4. Provide formulations that support the final form and stability of RNA vaccines and therapeutics

5. Application of QbD principles and assessment of program/project risks that relate to delivery vehicle, formulations, process scale-up/scale-down, and work with GMP, Regulatory, and Quality to manage riskes  

6. Execute Informal stability studies on RNA-LNP product candidates 

Minimum Required:

7. PhD with 1-2 years of experience

8. Experience with non-viral delivery systems for nucleic acids.

9. Preferred preparation of lipid nanoparticles and RNA or other nucleic acids

10. Prior experience executing technical risk assessments (TRA) and tech transfer of a discovery/early development program to a GMP manufacturer (internal or external)

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