分子胶初创公司招聘药理和药化（高级）总监

公司致力于降解蛋白的分子胶水类药物的研发。立足于癌症（包括肿瘤免疫）、代谢性疾病、罕见病等领域，开发具有靶向“不可成药”靶点的新型小分子蛋白降解剂。

公司创始团队拥有几十年蛋白泛素化降解领域的建树和新药开发商业运作的成就，并组建了强大的研发团队，已建立具有完全自主知识产权的molecular glue discovery平台。

1）Director / SD of Medicinal Chemistry

Key Responsibilities:

· Design, implement and execute medicinal chemistry strategies

· Establish partnering strategies to leverage external knowledge and capabilities

· Effectively plan resource allocation to achieve team goals

· Provide strategic, scientific, and managerial leadership in an outsourced Medicinal Chemistry environment

· Collaborate and contribute to multidisciplinary drug discovery project teams

· Provide timely and well-organized reports to project teams

· Collaborate effectively with the leadership team and other departments and functions

Education & Experience Requirements:

·PhD in chemistry and 10+ years of experience in the biotech and/or pharmaceutical industry, with a strong track record of scientific innovation and success in delivering clinical candidates

· In-depth knowledge of the drug R&D process with expertise in the application of ADME/PK, pharmacology

· A leader with effective organizational, interpersonal, communication and managerial skills who can motivate and inspire others with their excitement for achieving the scientific vision

2）Director / SD of In Vivo Pharmacology & Biomarker Discovery

Key Responsibilities:

·      Develop and validate animal disease models by working with CROs

·      Evaluate in vivo efficacy, establish PK/PD relationship, and understand mechanism of action.

·      Develop assays to profile protein readouts in tissues from animal studies.

·      Develop assays to evaluate target engagement and downstream effects in human blood.

·      Use good practices for data record keeping and analysis.

·      Train and mentor junior scientists.

·      Draft technical sections in regulatory documents.

Education & Experience Requirements:

·      PhD in biology or related，with 5+ years of industry experience. Title/Level can be flexible based on experience.  

·      Extensive experience on in vivo pharmacology and familiar with different tumor and/or immunology models

·      Successful track record of delivering non-clinical pharmacology package to enable IND filing and early development of small molecule therapeutics

·      Experience of collaboration with CROs or external partners

·      Understand in disease biology for oncology or immunology therapeutic areas.

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