百奥赛图携手Envigo共同推进重度免疫缺陷B-NDG小鼠销售
中国北京，2021年9月28日 – 百奥赛图宣布与Envigo达成动物模型的销售合作。Envigo是一家提供涵盖范围广泛的研究模型及相关服务的跨国企业。双方将共同致力于推进重度免疫缺陷B-NDG小鼠模型在相关研究领域的广泛应用。Envigo作为区域独家供应商负责百奥赛图B-NDG小鼠在美国、欧洲和部分亚太地区的销售。
B-NDG小鼠是百奥赛图自主研发，通过在NOD-scid背景上敲除IL2rg基因构建而成的重度免疫缺陷小鼠。该小鼠缺乏成熟的T、B和功能性的NK细胞，并表现出细胞因子信号转导功能缺失，其重度免疫缺陷表型使得该小鼠能够被用来进行包括人免疫细胞在内的异种细胞移植实验。该模型广泛应用于肿瘤学、肿瘤免疫学、传染病和干细胞生物学等领域的研究和药物发现。
Envigo总裁兼首席执行官Adrian Hardy博士表示：“我们与百奥赛图的合作进一步扩大了Envigo客户可选择的模型种类。B-NDG小鼠模型与在此基础上构建的二代模型为重要治疗方法的研究及开发提供了现有免疫缺陷模型的强大替代产品。”
百奥赛图董事长兼首席执行官沈月雷博士表示：“两家公司都致力于为基础研究和药物开发提供优秀的临床前模型。 我们相信，基于百奥赛图构建的高质量小鼠模型以及Envigo世界先进的繁育设施和小鼠健康监测体系的合作可以更好地满足相关领域的需求。”
Beijing, China, [September 28th], 2021 – Biocytogen announces a collaboration with Envigo, a global organization offering the broadest range of research models and related services. The two companies are committed to supporting research applications of the triple immunodeficient B-NDG mouse. Envigo is the exclusive provider of B-NDG mice in the United States, Europe, and certain Asia-Pacific regions.
The triple immunodeficient B-NDG mouse model was independently designed and produced by Biocytogen. B-NDG mice were created by deleting the IL2rg gene from NOD-scid mice with severe immunodeficiency phenotype. Lacking mature T cells, B cells or functional NK cells, and displaying cytokine signaling deficiencies, this mouse model is highly immunodeficient and capable of supporting human immune cell transplantation. The model is widely used in research and drug discovery in many fields including oncology, immuno-oncology, infectious disease, and stem cell biology.
Dr Adrian Hardy, President and CEO of Envigo, commented: “Our collaboration with Biocytogen further expands the range of models available to Envigo’s customers. The B-NDG model and future models to follow, offer a robust alternative to existing immunodeficient models for critical research and the development of life-saving therapies.”
Dr Yuelei Shen, President and CEO of Biocytogen, said: “Both companies are dedicated to supply good non-clinical models for basic research and drug development. We believe that such collaboration leveraging the high quality of mouse models generated by Biocytogen and the state-of-the-art breeding facilities & health monitoring programs at Envigo can satisfy the needs in those related fields.”
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