Sci. China Chem. 2020年第3期目录
Science China Chemistry
2020年第3期
Senescent cells accumulate in tissues and organs because of DNA damage accumulation during aging and therapy, which impairs tissue functions, accelerates aging and promotes stemness of tumor cells. Therefore, the selective identification and removal of senescent cells including senescent cancer cells are very important to prolong life and improve the treatment efficacy of cancer therapy. In this paper, the authors integrated the high selectivity of enzyme-instructed self-assembly (EISA) and efficient reactive oxygen species (ROS) generating properties of a novel luminogen with aggregation-induced emission (AIE) characters to selectively identify and remove senescent cancer cells. They used the characteristics of overexpression of β-galactosidase in senescent cells to selectively produce nanomaterials with fluorescence activation and ROS capacity through EISA strategy. Upon light irradiation, the nanomaterials could emit strong red fluorescence and produce ROS that was toxic to senescent cancer cells, and therefore this strategy could be applied for the selective identification and removal of senescent cancer cells (see the article by Zhengfeng Gao, Heqi Gao, Debin Zheng, Tengyan Xu, Yaoxia Chen, Chunhui Liang, Ling Wang, Dan Ding & Zhimou Yang on pages 398‒403).
Highlights
Uranyl photocatalysis: precisely controlled oxidation of sulfides with ground-stateoxygen
Wei-Min He, Ying-Wu Lin, Dong-Hong Yu
Sci. China Chem. 63(3), 291-293 (2020)
Efficiency breakthrough for all-perovskite tandem solar cells
Tingming Jiang, Yang (Michael) Yang
Sci. China Chem. 63(3), 294-295 (2020)
Reviews
Peptide asparaginyl ligases—renegade peptide bond makers
James P. Tam, Ning-Yu Chan, Heng Tai Liew, Shaun J. Tan, Yu Chen
Sci. China Chem. 63(3), 296-307 (2020)
Synthetic fluorescent probes to apprehend calcium signalling in lipid droplet accumulation in microalgae—an updated review
AHM Mohsinul Reza, Javad Tavakoli, Yabin Zhou, Jianguang Qin, Youhong Tang
Sci. China Chem. 63(3), 308-324 (2020)
Communications
Improving open-circuit voltage by a chlorinated polymer donor endows binary organic solar cells efficiencies over 17%
Ruijie Ma, Tao Liu, Zhenghui Luo, Qing Guo, Yiqun Xiao, Yuzhong Chen, Xiaojun Li, Siwei Luo, Xinhui Lu, Maojie Zhang, Yongfang Li, He Yan
Sci. China Chem. 63(3), 325-330 (2020)
Palladium-catalyzed regioselective cascade reaction of carbon dioxide, amines and allenes for the synthesis of functionalized carbamates
Wenfang Xiong, Ruixiang Cheng, Bowen Wu, Wanqing Wu, Chaorong Qi, Huanfeng Jiang
Sci. China Chem. 63(3), 331-335 (2020)
Para-selective borylation of monosubstituted benzenes using a transient mediator
Jie Wu, Zengwei Wang, Xiao-Yue Chen, Yichen Wu, Daoming Wang, Qian Peng, Peng Wang
Sci. China Chem. 63(3), 336-340 (2020)
Articles
Widespread arginine phosphorylation in human cells—a novel protein PTM revealed by masss pectrometry
Songsen Fu, Chuan Fu, Quan Zhou, Rongcan Lin, Han Ouyang, Minning Wang, Ying Sun, Yan Liu, Yufen Zhao
Sci. China Chem. 63(3), 341-346 (2020)
A bioinspired magnetic responsive cilia array surface for microspheres underwater directional transport
Shuang Ben, Jinjia Yao, Yuzhen Ning, Zhihong Zhao, Jinlong Zha, Dongliang Tian, Kesong Liu, Lei Jiang
Sci. China Chem. 63(3), 347-353 (2020)
Identifying the active photocatalytic H2-production sites on TiO2-supported Pt nanoparticles by the in-situ infrared spectrum of CO
Peng Zhou, Hongna Zhang, Hongwei Ji, Wanhong Ma, Chuncheng Chen, Jincai Zhao
Sci. China Chem. 63(3), 354-360 (2020)
Zhenghui Luo, Rui Sun, Cheng Zhong, Tao Liu, Guangye Zhang, Yang Zou, Xuechen Jiao, Jie Min, Chuluo Yang
Sci. China Chem. 63(3), 361-369 (2020)
Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions
Hang Chen, Dong-Huang Chen, Pei-Qiang Huang
Sci. China Chem. 63(3), 370-376 (2020)
Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM-co-2-AAPBA)
Qingxian Wang, Mian Fu, Ying Guan, Tony D. James, Yongjun Zhang
Sci. China Chem. 63(3), 377-385 (2020)
A visible-light-photocatalytic water-splitting strategy for sustainable hydrogenation/deuteration of aryl chlorides
Xiang Ling, Yangsen Xu, Shaoping Wu, Mofan Liu, Peng Yang, Chuntian Qiu, Guoqiang Zhang, Hongwei Zhou, Chenliang Su
Sci. China Chem. 63(3), 386-392 (2020)
Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo
Jianlei Shen, Kun Tao, Peilin Gu, ChenGui, Dong Wang, Zhenyu Tan, Lihua Wang, Zhiming Wang, Anjun Qin, Ben Zhong Tang, Shisan Bao
Sci. China Chem. 63(3), 393-397 (2020)
β-Galactosidase responsive AIE fluorogene for identification and removal of senescent cancer cells
Zhengfeng Gao, Heqi Gao, Debin Zheng, Tengyan Xu, Yaoxia Chen, Chunhui Liang, Ling Wang, Dan Ding, Zhimou Yang
Sci.China Chem. 63(3), 398-403 (2020)
A pH-regulated stimuli-responsive strategy for RNA-cleaving DNAzyme
Shasha Lu, Shuang Wang, Jiahui Zhao, Jian Sun, Xiurong Yang
Sci. China Chem. 63(3), 404-410 (2020)
Probing non-polarizable liquid/liquid interfaces using scanning ion conductance microscopy
Yaxiong Gu, Ye Chen, Yifan Dong, Junjie Liu, Xianhao Zhang, Mingzhi Li, Yuanhua Shao
Sci. China Chem. 63(3), 411-418 (2020)
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